Backed by Research

HOTSHOT for Muscle Cramps has been proven to work by researchers at Penn State University and in multiple field studies. HOTSHOT has been shown to significantly reduce muscle-cramp intensity and duration compared to placebo. Among heavy crampers, HOTSHOT has been shown to prevent muscle cramps by over 50% during and after a workout when used 15–30 minutes before the workout. Our results were presented at the American Academy of Neurology and the Society for Neuroscience and published in Muscle & Nerve Magazine and the Journal of the American Medical Athletic Association.

HOTSHOT for Muscle Soreness is made with all natural, plant based ingredients that have been scientifically proven to help the body’s production of Nitric Oxide (NO) during exercise which in turn helps promote vasodilation and blood flow. Increasing NO and vasodilation can enhance oxygen and nutrient delivery to active muscles which helps improve tolerance to physical exercise and speed up recovery.

HOTSHOT also conducted an in-home use test among 288 athletes using the base formula but to specifically understand the soreness benefit. In that study, 92% of respondents claimed less muscle pain the next day, 84% claimed they felt less muscles soreness and 88% said their next day workouts were better because they felt less muscle soreness.

Interested in our science? Email us for more information.



HOTSHOT was invented by an endurance athlete/ Nobel Prize-Winning Neuroscientist. HOTSHOT’s proprietary formulation was developed after five years of scientific research which revealed a surprising truth: preventing muscle cramps is not about treating the muscles, it’s about treating the nerves.

Our Story
  • Muscle cramps and soreness start when your nerves become hyper-excited and blast your tired muscles with repetitive, uncontrollable signals.

  • Drinking a 1.7 oz HOTSHOT Sports Shot starts to work by triggering the sensory nerves located in your mouth and esophagus.

  • Those stimulated nerves then send a calming signal to your spinal cord.

  • The signals inhibit the repetitive firing of hyperactive nerves into your muscles — to quickly stop muscle cramps and reduce next-day muscle soreness.

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