Our Story

Where It All Began

An Endurance Athlete/Nobel Prize-Winner Takes on Muscle Cramping and Soreness.

HOTSHOT was founded by Nobel Prize-Winner, Dr. Rod Mackinnon, and his friend Dr. Bruce Bean. While deep sea kayaking together one winter, they were both seized with life-threatening muscle cramps. They experienced such debilitating pain that neither could steady their kayaks. While they survived the excruciating moment, it flipped the switch on their curiosity – Why do we cramp? What is the cure? As neuroscientists, they were uniquely qualified to find the answer.

scientists inducing leg cramp
Calling upon his Nobel Prize-winning expertise on ion channels, Dr. MacKinnon reasoned that preventing and treating cramps must begin in the nerve, not the muscle. Together with Dr. Bean, they discovered muscle cramping is triggered by hyperactive nerves that can get over-excited with exercise and repetitively fire into the muscle. This repetition is what triggers a cramp and can cause lingering soreness.
close up of athlete holding HOTSHOT bottle
With this breakthrough understanding and 5 years of research, they created a powerful and effective 1.7 oz Sports Shot that quickly targets and calms the hyperactive nerves. Stopping muscle cramps and soreness where they start and revolutionizing the possibilities of athletic performance. Originally tested under the codename #itsthenerve, HOTSHOT was launched in May of 2016.
team in huddle with all hands in
Today HOTSHOT is the only scientifically proven product to prevent and treat muscle cramps. We are proud to serve over 600 professional, college and high school teams across the country — and a growing army of endurance athletes, weekend warriors and exercise enthusiasts in between. Our mission at HOTSHOT is to continue to break down barriers and obstacles to better performance for athletes everywhere.